No. All our hosting plans do not require you to have knowledge of that operating system. For the most part, the webserver is transparent to the user.
The cPanel Control panel on Linux will help you manage things like email creation, common script (like Formmail) installations, and backup. If you know how to use a mouse and keyboard, you will be able to manage your website with our control panel.
Note: This does not mean that our control panel will create your website. You will still need to have knowledge of how to create and design your website.